Revealing the secrets of histone H3 modification
نویسندگان
چکیده
منابع مشابه
Revealing the Secrets of David Parnas
Those of us in the fast-changing field of computing often dismiss anything written more than five years ago as obsolete. Yet several decades-old papers by David L. Parnas [1, 4, 5, 6, 7, 8] are as timely as those published in recent issues of the top journals. Parnas articulates the timeless software design concepts known as information hiding and abstract interfaces. Most programmers would des...
متن کاملNuclear levels and patterns of histone H3 modification and HP1 proteins after inhibition of histone deacetylases.
The effects of the histone deacetylase inhibitors (HDACi) trichostatin A (TSA) and sodium butyrate (NaBt) were studied in A549, HT29 and FHC human cell lines. Global histone hyperacetylation, leading to decondensation of interphase chromatin, was characterized by an increase in H3(K9) and H3(K4) dimethylation and H3(K9) acetylation. The levels of all isoforms of heterochromatin protein, HP1, we...
متن کاملRevealing water’s secrets: deuterium depleted water
BACKGROUND The anomalous properties of water have been of great interest for generations of scientists. However the impact of small amount of deuterium content which is always present in water has never been explored before. For the first time the fundamental properties of deuterium depleted (light) water at 4°C and 20°C are here presented. RESULTS The obtained results show the important role...
متن کاملRecognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1.
Multiple covalent modifications on a histone tail are often recognized by linked histone reader modules. UHRF1 [ubiquitin-like, containing plant homeodomain (PHD) and really interesting new gene (RING) finger domains 1], an essential factor for maintenance of DNA methylation, contains linked two-histone reader modules, a tandem Tudor domain and a PHD finger, tethered by a 17-aa linker, and has ...
متن کاملToxoplasma gondii Inhibits Covalent Modification of Histone H3 at the IL-10 Promoter in Infected Macrophages
Infection of macrophages with the protozoan parasite Toxoplasma gondii results in inhibition of a large panel of LPS-responsive cytokines, including TNF-alpha, while leaving others such as IL-10 intact. Recent studies provide evidence that the parasite interferes with chromatin remodeling at the TNF-alpha promoter that is normally associated with LPS stimulation, but that is not required for TL...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Proteome Research
سال: 2008
ISSN: 1535-3893,1535-3907
DOI: 10.1021/pr800556r